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Effect of beta-blocking agents on peroperative changes in serum phosphate
Acta Chirurgica Scandinavica
|January 1, 1982
Summary
Surgical trauma can cause a rapid drop in serum phosphate levels. Beta-blocking agents prevent this drop, suggesting catecholamines mediate the effect of trauma on phosphate levels.
Area of Science:
- Biochemistry
- Endocrinology
- Surgical Physiology
Background:
- Hypophosphataemia post-surgery is often linked to glucose infusion or hemodilution.
- Trauma itself can induce hypophosphataemia as part of the body's response.
- Previous studies in pigs indicated a bi-phasic fall in serum phosphate post-trauma, preventable by beta-blockers.
Purpose of the Study:
- To investigate the role of beta-blocking agents in preventing peroperative hypophosphataemia.
- To test the hypothesis that catecholamine release mediates the rapid fall in serum phosphate after surgical trauma.
Main Methods:
- Compared peroperative serum phosphate levels in thyrotoxic patients on beta-blockers undergoing thyroid surgery.
- Compared these levels with patients not on beta-blockers undergoing similar or other elective surgeries.
Main Results:
- The peroperative fall in serum phosphate was prevented in patients treated with beta-blocking agents.
- This prevention was observed in patients undergoing elective thyroid surgery.
Conclusions:
- The findings support the hypothesis that catecholamines mediate the rapid, trauma-induced fall in serum phosphate.
- Beta-blocking agents may play a role in managing peroperative phosphate variations.