Selective potentiation of retinal horizontal cell responses to L-glutamate by D-aspartate

1. L-Glutamate and L-aspartate depolarize type H1 horizontal cells in the isolated retina of goldfish, but only at millimolar concentrations. 2. When applied in the presence of D-aspartate, L-glutamate depolarizes H1 cells at concentrations nearly 15-fold lower than when it is applied alone. The effects of L-aspartate were not potentiated by either D-aspartate or D-glutamate. 3. Since D-aspartate seems also to enhance the effect of the transmitter released by cone photoreceptors, these results are consistent with the possibility that L-glutamate is a neurotransmitter of cones.