Testosterone : testosterone estradiol binding globulin ratio in evaluating hirsute women

Testosterone : testosterone estradiol binding globulin (TEBG) ratio is evaluated in 35 hirsute women (age 12 to 38 years), and 14 healthy nonhirsute normal controls (age 21 to 40 years). This is an attempt to emphasize the significance of TEBG in evaluating hirsute women. This is a significant negative linear correlation between the weight of the patients and TEBG concentrations (r = 0.414, P less than 0.05). There is negative linear correlation between TEBG and serum free testosterone concentration that reached significance only in the hirsute nonobese. T:TEBG ratio is significantly high in hirsute women compared to the controls. T:TEBG ratio shows a significant positive linear correlation with free testosterone concentration. In addition, T:TEBG ratio is a direct simple method of evaluating hirsute women. Demulen and Dexamethazone treatment produced a significant fall in T:TEBG ratio in hirsute women.