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Assay for type C virus in mouse sera based on particulate reverse transcriptase activity.

P Roy-Burman, M Dougherty, B K Pal

    Journal of Virology
    |September 1, 1976
    PubMed
    Summary
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    Measuring reverse transcriptase activity in feral mice sera is a quick and sensitive method to detect type C virus infection. This assay correlates well with other virus detection methods.

    Area of Science:

    • Virology
    • Immunology
    • Biochemistry

    Background:

    • Feral mice are a natural reservoir for type C viruses.
    • Accurate detection of in vivo virus infection is crucial for epidemiological studies.

    Purpose of the Study:

    • To establish a sensitive and rapid assay for detecting type C virus infection in feral mice.
    • To evaluate the efficacy of reverse transcriptase activity assay compared to existing methods.

    Main Methods:

    • Assay of particulate reverse transcriptase activity in serum samples from naturally infected feral mice.
    • Comparison of results with assays for infectious virus, complement fixation, and competitive radio-immunoassays for the p30 internal antigen.

    Main Results:

    • The reverse transcriptase activity assay is a sensitive and rapid method for determining in vivo type C virus infection.

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  • The assay results showed good correlation with established methods for virus detection and antigen quantification.

    • Conclusions:

    • Particulate reverse transcriptase activity assay is a reliable and efficient tool for diagnosing type C virus infection in feral mice.
    • This method offers a valuable alternative for monitoring virus prevalence in wildlife populations.