Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Wearable artificial endocrine pancrease with needle-type glucose sensor.

M Shichiri, R Kawamori, Y Yamasaki

    Lancet (London, England)
    |November 20, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Stimulation of the hamster ventral lateral geniculate nucleus induces Fos-like immunoreactivity in suprachiasmatic nucleus cells.

    Neuroscience letters·1992
    Same author

    Papillary craniopharyngioma of the third ventricle--case report.

    Neurologia medico-chirurgica·1992
    Same author

    Sequential change of heterogeneous cerebral blood blow patterns after diffuse brain ischemia.

    Resuscitation·1992
    Same author

    Cerebral infarction in a heterozygote with variant antithrombin III.

    Stroke·1992
    Same author

    Ocular convergence-related neuronal responses in the lateral suprasylvian area of alert cats.

    Neuroscience research·1992
    Same author

    [Evaluation of cerebral blood circulation using fast magnetic resonance imaging (turbo-FLASH)].

    No shinkei geka. Neurological surgery·1992

    Researchers developed a miniaturized artificial pancreas with a novel needle-type glucose sensor. This wearable device successfully controlled blood glucose in dogs for up to 7 days, paving the way for long-term diabetes management.

    Area of Science:

    • Biomedical Engineering
    • Endocrinology
    • Diabetes Technology

    Background:

    • Long-term diabetes management requires restoring physiological glycemic control.
    • Miniaturization of artificial endocrine pancreas systems is crucial for patient use.
    • Developing small, reliable glucose monitoring systems remains a challenge for closed-loop artificial pancreas development.

    Purpose of the Study:

    • To develop and evaluate a miniaturized wearable artificial endocrine pancreas for long-term glycemic control.
    • To integrate a novel needle-type glucose sensor into a closed-loop system.
    • To assess the efficacy of the artificial pancreas in a preclinical model.

    Main Methods:

    • Development of a needle-type glucose sensor suitable for closed-loop systems.

    Related Experiment Videos

  • Integration of the sensor with a computer algorithm for calculating insulin and glucagon infusion rates.
  • Testing of the wearable artificial endocrine pancreas in pancreatectomized dogs.

    • Main Results:

    • A functional needle-type glucose sensor was successfully developed.
    • The wearable artificial endocrine pancreas demonstrated perfect blood glucose control in dogs.
    • Effective glycemic management was sustained for up to 7 days in the animal model.

    Conclusions:

    • The miniaturized wearable artificial endocrine pancreas with an integrated needle-type glucose sensor shows promise for long-term diabetes management.
    • This technology represents a significant advancement in creating sophisticated, implantable artificial pancreas systems.
    • The successful preclinical trials support further development towards clinical application in diabetic patients.