[Comparative pharmacokinetics of benzodiazepines]

The pharmetabolism properties allow to guide the therapeutic use of benzodiazepines. The authors have studied these two aspects in relation with absorption, routes of administration, protein binding, distribution, métabolism, excretion, long-term use. The paper also deals extensively with pharmacokinetics and metabolic modifications under the influence of drug interaction, age, physiologic condition (pregnancy, new-born, elderlies) and pathological condition. These data are useful to guide the choice according to indication and to adapt the dosage.