Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thyroid-stimulating immunoglobulins.

A Pinchera, G F Fenzi, E Macchia

    Hormone Research
    |January 1, 1982
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The size of the community rather than its geographical location better defines the risk of iodine deficiency: results of an extensive survey in Southern Italy.

    Journal of endocrinological investigation·2013
    Same author

    Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.

    Journal of endocrinological investigation·2013
    Same author

    The effect of voluntary iodine prophylaxis in a small rural community: the Pescopagano survey 15 years later.

    The Journal of clinical endocrinology and metabolism·2013
    Same author

    Inverse relationship of food and alcohol intake to sleep measures in obesity.

    Nutrition & diabetes·2013
    Same author

    In vivo assessment about the effects of a diet containing iodine-enriched foodstuffs. A pilot study in 30 volunteers.

    Journal of endocrinological investigation·2012
    Same author

    Foreword.

    Journal of endocrinological investigation·2012
    Same journal

    Abstracts of the LWPES/ESPE 8th Joint Meeting Global Care in Paediatric Endocrinology, in collaboration with APEG, APPES, JSPE and SLEP. New York City, New York, USA. September 9-12, 2009.

    Hormone research·2011
    Same journal

    Abstracts of the 47th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE). Istanbul, Turkey. September 20-23, 2008.

    Hormone research·2011
    Same journal

    Abstracts of the 46th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE). Helsinki, Finland. June 27-30, 2007.

    Hormone research·2011
    Same journal

    Genetic and pathogenetic aspects of Noonan syndrome and related disorders.

    Hormone research·2009
    Same journal

    Response to growth hormone in short children with Noonan syndrome: correlation to genotype.

    Hormone research·2009
    Same journal

    Growth hormone and the heart in Noonan syndrome.

    Hormone research·2009
    See all related articles

    Thyroid-stimulating immunoglobulins cause Graves' disease hyperthyroidism. Measuring these antibodies can predict relapse, but current assays are difficult, highlighting the need for simpler tests.

    Area of Science:

    • Endocrinology
    • Immunology
    • Autoimmune Diseases

    Background:

    • Graves' disease is characterized by thyroid-stimulating immunoglobulins (TSIs).
    • TSIs are antibodies targeting a thyroid plasma membrane antigen, possibly related to the TSH receptor.
    • The causal role of TSIs in Graves' hyperthyroidism is well-established.

    Purpose of the Study:

    • To explore the role of TSIs in Graves' disease.
    • To discuss the clinical implications of TSI measurements, particularly for predicting hyperthyroid relapse.
    • To emphasize the need for improved diagnostic assays.

    Main Methods:

    • Utilized human-specific stimulation assays to overcome limitations of previous studies.
    • Reviewed existing evidence on TSI function and their relationship with thyroid parameters.

    Related Experiment Videos

  • Discussed factors influencing TSI assay reliability and clinical utility.

    • Main Results:

    • Individual thyroid response variations and interfering antibodies can affect the correlation between TSI levels and thyroid function.
    • TSI determinations show promise in predicting hyperthyroid relapse in treated Graves' disease patients.
    • Current technical challenges limit the routine clinical application of TSI assays.

    Conclusions:

    • Accurate measurement of TSIs is crucial for managing Graves' disease.
    • Development of simple, reliable assays for TSI measurement is essential for routine clinical use.
    • Further research is needed to fully understand the TSI antigen and its interaction with the TSH receptor.