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Menopausal status and haemostatic variables.

T W Meade, A P Haines, J D Imeson

    Lancet (London, England)
    |January 1, 1983
    PubMed
    Summary
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    Postmenopausal women have a higher risk of ischaemic heart disease (IHD) due to elevated levels of factor VIIC and fibrinogen. These haemostatic differences contribute significantly to the increased IHD risk observed in older women.

    Area of Science:

    • Cardiovascular Health
    • Menopause Research
    • Haemostasis and Thrombosis

    Background:

    • Ischaemic heart disease (IHD) incidence is notably higher in postmenopausal women compared to age-matched premenopausal women.
    • Haemostatic function differences between these groups are hypothesized to contribute to the disparity in IHD risk.

    Purpose of the Study:

    • To investigate the role of haemostatic function differences in the increased IHD risk observed in postmenopausal women.
    • To compare levels of specific coagulation factors and lipids between premenopausal and postmenopausal women.

    Main Methods:

    • The Northwick Park Heart Study (NPHS) cohort, comprising 833 White women, was analyzed.
    • Mean levels of factor VIIC, fibrinogen, and cholesterol were measured and compared between premenopausal and postmenopausal participants.

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    Main Results:

    • Postmenopausal women exhibited 6-10% higher mean levels of factor VIIC, fibrinogen, and cholesterol compared to premenopausal women.
    • After adjusting for inter-variable associations, the significant difference in cholesterol levels between the groups diminished.
    • Factor VIIC and fibrinogen differences, however, remained significant.

    Conclusions:

    • Elevated levels of factor VIIC and fibrinogen in postmenopausal women are associated with increased IHD risk.
    • These haemostatic changes may account for approximately 40% of the increased risk of fatal IHD in postmenopausal women compared to premenopausal women.