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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

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Coeliac disease and malignancy.

C M Swinson, G Slavin, E C Coles

Lancet (London, England)

|January 15, 1983

Summary

This summary is machine-generated.

Patients with coeliac disease face a higher risk of developing cancers, especially lymphomas and small-intestinal adenocarcinomas. This study highlights the increased cancer risk in individuals with coeliac disease.

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

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Published on: April 11, 2025

Area of Science:

Gastroenterology
Oncology
Epidemiology

Background:

Coeliac disease (CD) is an autoimmune disorder triggered by gluten ingestion.
Individuals with CD have a known increased risk for certain cancers, particularly gastrointestinal lymphomas.

Purpose of the Study:

To investigate the spectrum and incidence of malignant neoplasms in patients diagnosed with coeliac disease.
To compare cancer risks in coeliac disease patients with the general population.

Main Methods:

Retrospective analysis of 235 patients with histologically confirmed coeliac disease.
Review of 259 histologically confirmed malignancies diagnosed in these patients.
Comparison of observed cancer incidence with national cancer registration data adjusted for age and sex.

Main Results:

133 of the malignancies were malignant lymphomas, with malignant histiocytosis being the predominant type, primarily affecting the small intestine.
A significantly increased risk for small-intestinal adenocarcinomas was observed (19 cases vs. 0.23 expected).
Elevated rates of oesophageal and pharyngeal squamous cell carcinomas were also noted.

Conclusions:

Coeliac disease is associated with a substantially elevated risk of developing malignant neoplasms, including lymphomas and adenocarcinomas.
The small intestine is a common site for these malignancies in coeliac disease patients.
Further research and surveillance are warranted for coeliac disease patients regarding cancer risk.