The distribution of amyloid P component in normal human skin

The distribution of amyloid P component in normal human adult skin was studied using fluorescent immunohistochemical techniques on frozen sections. Amyloid P component is associated with elastic fibres of all sizes, and is present in the basement membrane of sweat gland ducts. It is not demonstrable in the basement membrane at the epidermo-dermal junction or in the secretory portion of the sweat glands. In the latter site there is however a spiral, fibrillar, elastic plexus closely related to the basement membrane.