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[Effect of adrenoblockaders on gastric secretion]
Farmakologiia I Toksikologiia
|November 1, 1982
Summary
Phentolamine significantly increases gastric secretion, including hydrochloric acid and pepsin, in dogs and patients with atrophic gastritis. Propranolol showed no effect on gastric secretion in this study.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Histamine stimulates gastric acid secretion.
- Alpha-adrenergic blockers like phentolamine may influence gastric function.
- Beta-blockers like propranolol are not typically associated with direct effects on gastric secretion.
Purpose of the Study:
- To investigate the effects of phentolamine and propranolol on histamine-induced gastric secretion in dogs.
- To evaluate the therapeutic potential of phentolamine in patients with atrophic gastritis.
Main Methods:
- Dogs were operated on using the V. A. Basov's method to assess gastric secretion.
- Phentolamine and propranolol were administered at a dose of 2.5 mg/kg to dogs.
- Phentolamine was administered to patients with atrophic gastritis at a dose of 0.025 mg/kg three times daily for 10 days.
Main Results:
- Phentolamine increased gastric secretion rate by 2.6 times, hydrochloric acid output by 4.4 times, and pepsin and chloride secretion by 2.5 times in dogs.
- Propranolol had no significant effect on gastric secretion in dogs.
- In patients with atrophic gastritis, phentolamine increased secretion rate and pepsin secretion by 1.8 times and hydrochloric acid output by 2.8 times.
Conclusions:
- Phentolamine enhances gastric secretion, suggesting a role for alpha-adrenergic receptors in its regulation.
- Propranolol does not appear to influence histamine-stimulated gastric secretion.
- Phentolamine may hold therapeutic value for conditions characterized by reduced gastric secretion, such as atrophic gastritis.