[Effect of adrenoblockaders on gastric secretion]

The effects of phentolamine and propranolol in doses 2.5 mg/kg on histamine gastric secretion were examined in dogs operated on according to the V. A. Basov's method. It was ascertained that phentolamine raised the secretion rate by 2.6 times, the hourly output of hydrochloric acid by 4.4 times, secretion of pepsin and chlorides by 2.5 times. Propranolol did not affect gastric secretion. Administration of phentolamine in a dose of 0.025 mg/kg three times a day for 10 days ta patients with a moderately pronounced atrophic gastritis increased the secretion rate and pepsin secretion by 1.8 times. The hourly output of hydrochloric acid rose by 2.8 times.