Acute effects of buspirone and alcohol on psychomotor skills

Acute psychomotor and psychological effects of oral buspirone (10 and 20 mg) with and without alcohol (1 g/kg) were studied in a double-blind crossover trial in 12 young males. Treatments were administered at 1-week intervals in balanced order. Buspirone failed to impair objective performance but caused drowsiness and fatigue. The reference drug lorazepam (2.5 mg) impaired skills objectively, with less subjective impairment. Lorazepam, but not buspirone, interacted with alcohol.