Blood levels and the quantitative EEG response to CNS-active drugs: retrospective observations

Quantitative EEG measures provide reliable, non-invasive indices of CNS effects of drugs in man. In pharmaco-EEG studies of CNS-active substances, we found that EEG changes correlated with blood drug levels within individuals over time, and showed the correlation to be replicable. Across individuals at single times, however, correlations were not evident. In seeking relationships across subjects, techniques which adjust for EEG baseline differences between subjects are under investigation.