[Comparative effect of antiglaucoma preparations on brain bioelectrical activity]

Experiments on unanesthetized rabbits with electrodes implanted in different areas of the cortex and subcortical structures of the brain have demonstrated that when administered to the conjunctival sac of the eye, the drugs used as eye drops for glaucoma treatment affect brain bioelectrical activity and the ECG. Aceclidine, physostigmine and clofelin produce the most remarkable action. Phosphacol and pilocarpine are less active. Aceclidine and physostigmine effects are characterized by pronounced activation of the EEG. On the contrary, clofelin produces the synchronization of bioelectrical activity. The activation effect of aceclidine and physostigmine is reduced or blocked by conjunctival administration of atropine and benactizine.