[Pharmacological actions of oxatomide (KW-4354). 3. Actions on experimental asthma and Schultz-Dale reaction]

The present experiment was carried out to elucidate the effectiveness of oxatomide for prophylaxis in the bronchial anaphylaxis and Schultz-Dale response. 1) Oxatomide administered i.v. was found to be as active as disodium cromoglycate (DSCG) in inhibiting IgE-mediated active anaphylactic bronchoconstrictions in rats. In contrast to DSCG, oxatomide was effective when administered p.o. 2) Passive anaphylactic broncho-constrictions in guinea pigs mediated IgG-like rabbit antibody against egg albumin was also prevented dose-dependently by treatment with oxatomide given p.o. and i.v., but not by DSCG. 3) Oxatomide and DSCG inhibited passive anaphylactic bronchoconstrictions in guinea pigs mediated by IgE-like antibody against BPO X BGG. 4) The anaphylactic reaction of the isolated guinea pig ileum, the so-called Schultz-Dale reaction, showed a bi-phasic response: a short, rapid contraction followed by a partial relaxation and a slow contractile response. Oxatomide significantly depressed both the rapid first contraction and the slow sustained one. 5) Oxatomide administered after the development of antigen-induced contraction of isolated guinea pig trachea resulted in relaxation. These results suggest that oxatomide may be effective for the treatment of allergic bronchial asthma.