[Effect of combination of inderal with nitrites on the contractile function of the heart in experimental coronary occlusion]
Related Experiment Video
Updated: Aug 16, 2026

Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption
Published on: August 16, 2016
Abstract:
In acute experiments on 29 dogs with coronary occlusion changes in cardiohaemodynamics, epicardial electrogram and the regional contractility of the myocardium were studied with the aid of echocardiography after combined administration of inderal with nitroglycerin or sodium nitroprusside. It was established that under these conditions nitrites retain their ability to decrease the load on the heart: they decrease the end diastolic pressure and the volume of the cavity of the left ventricle, enhance the productivity of the heart Nitrites given with inderal do not change the contractility of the ischemized area and also do not affect the magnitude of the rise of ST segment of the epicardium electrogram of the ischaemic zone. It is concluded that the use of nitrites in acute myocardial ischaemia combined with inderal is justified to decrease congestive insufficiency of the heart, excepting cases with marked hypotension.
More Related Videos
08:01Semi-Minimal Invasive Method to Induce Myocardial Infarction in Rats and the Assessment of Cardiac Function by an Isolated Working Heart System
Published on: June 11, 2020
08:46Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels
Published on: March 22, 2024
Related Concept Videos
Nitric Oxide Signaling Pathway
Heart Failure Drugs: Inotropic Agents
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...