Related Experiment Video
Updated: Aug 17, 2026

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
Use of statistics in the analysis of side effect data from clinical trials of psychoactive agents
Abstract:
1. Evaluation of the side effects of psychoactive drugs presents a special statistical situation because many of the symptoms of psychiatric disorders are also potential side effects. 2. Reported incidences of adverse events can be viewed as being a combination of psychoactive drug effects, disease state effects and other concomitant effects. 3. An intriguing statistical problem is to develop methodology to separate these effects. 4. This paper discussed four methodologies for estimating incidence of side effects assessed with a symptom and side effect check list.
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