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[Changes in the GABA-transaminase activity in various structures of the rat brain after administration of
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|January 1, 1983
Abstract:
Quantitative histochemistry was used to study the effects of phenazepam, medazepam, diazepam, and nitrazepam on GABA-transaminase activity in different rat brain structures. Phenazepam and diazepam, which produced anxiolytic effect in low doses, selectively inhibited GABA-transaminase of the hippocamp. The degree of GABA-transaminase inhibition corresponded with pharmacological activity of the test benzodiazepines. It is assumed that inhibition of brain GABA-transaminase by benzodiazepines is linked with their interaction with GABA-benzodiazepine receptor complex.