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Development of the enteric nervous system.

M D Gershon, R F Payette, T P Rothman

    Federation Proceedings
    |April 1, 1983
    PubMed
    Summary
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    The enteric nervous system (ENS) exhibits remarkable neuronal diversity. Gut microenvironment signals may influence how neural crest cells develop into various enteric neuron types.

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Gastroenterology

    Background:

    • The mature enteric nervous system (ENS) displays significant neuronal diversity and autonomy from the central nervous system.
    • Neural crest precursors colonize the gut and commit to neuronal lineages early, but phenotypic expression occurs within the gut.
    • A persistent population of proliferating neuroblasts exists in the developing gut.

    Purpose of the Study:

    • To investigate the factors influencing neuronal phenotypic expression within the developing enteric nervous system.
    • To explore the role of the enteric microenvironment in shaping neuronal diversity.

    Main Methods:

    • Utilizing immunocytochemistry to detect neurofilament protein.
    • Culturing primordial gut explants to observe neuronal development.

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  • Analyzing patterns of neuronal phenotypic expression in mouse models.

    • Main Results:

    • Enteric neuron precursors are committed to the neuronal lineage upon gut colonization.
    • Neuronal phenotypic expression occurs within the gut, with a proximodistal wave observed in mice.
    • This wave of expression does not correlate with precursor cell migration patterns.

    Conclusions:

    • The enteric microenvironment may play a crucial role in influencing enteric neuronal phenotypic expression.
    • The plasticity of neural crest-derived neurons and the presence of proliferating neuroblasts suggest environmental modulation of neuronal fate.