Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurotensin stimulates defaecation.

J Calam, R Unwin, W S Peart

    Lancet (London, England)
    |April 2, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Neurotensin significantly increased colonic motility in healthy adults, leading to defecation and bowel sounds. This peptide may play a role in gastrointestinal disorders associated with diarrhea.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells resistant to PI3K inhibition.

    Oncogene·2016
    Same author

    Does hypokalaemia cause nephropathy? An observational study of renal function in patients with Bartter or Gitelman syndrome.

    QJM : monthly journal of the Association of Physicians·2011
    Same author

    Medical Investigation of Retinal Vascular Occlusion.

    British medical journal·2010
    Same author

    Lectins: from basic science to clinical application in cancer prevention.

    Expert opinion on investigational drugs·2005
    Same author

    Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf.

    Veterinary parasitology·2002
    Same author

    ABC of the upper gastrointestinal tract: Pathophysiology of duodenal and gastric ulcer and gastric cancer.

    BMJ (Clinical research ed.)·2001
    Same journal

    Rethinking anticoagulation intensity during extracorporeal membrane oxygenation.

    Lancet (London, England)·2026
    Same journal

    Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial.

    Lancet (London, England)·2026
    Same journal

    Inherited retinal degenerations: clinical phenotypes and emerging therapies.

    Lancet (London, England)·2026
    Same journal

    Documenting hospice care.

    Lancet (London, England)·2026
    Same journal

    After the wood chipper.

    Lancet (London, England)·2026
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    See all related articles

    Area of Science:

    • Gastroenterology
    • Neuroendocrinology
    • Human Physiology

    Background:

    • Neurotensin is a peptide hormone found in the gastrointestinal tract.
    • Elevated plasma neurotensin levels are observed in certain conditions causing diarrhea.
    • The specific role of neurotensin in colonic motility remains to be fully elucidated.

    Purpose of the Study:

    • To investigate the effect of neurotensin on human colonic motility.
    • To determine if neurotensin administration influences defecation and bowel sounds.

    Main Methods:

    • A double-blind study was conducted on five healthy adult volunteers.
    • Participants received intravenous infusions of neurotensin (13.5 pmol kg-1 min-1 for 30 min) or a control infusion.
    • Defecation, borborygmi, and stool characteristics were monitored.

    Related Experiment Videos

    Main Results:

    • All five participants receiving neurotensin experienced defecation within 2.5 hours.
    • Neurotensin induced borborygmi and produced stools similar in consistency and electrolyte content to normal colonic contents.
    • Infusion levels of neurotensin were approximately three times higher than normal postprandial concentrations.

    Conclusions:

    • Neurotensin significantly enhances propulsive colonic motility in humans.
    • The findings suggest a potential physiological role for neurotensin in regulating bowel movements.
    • Further research is warranted to explore the implications of neurotensin in diarrheal diseases.