Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypertriglyceridaemia and hypercoagulability.

H C Simpson, J I Mann, T W Meade

    Lancet (London, England)
    |April 9, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Seasonal variations in sources of dissolved inorganic carbon in the Godavari estuary (India) using stable carbon isotopes.

    Environmental science and pollution research international·2025
    Same author

    Chronic Atrophic Orchitis in a Bull.

    The Journal of comparative medicine and veterinary archives·2022
    Same author

    The management of menopausal symptoms in women following treatment for cancer at a specialist menopause service.

    Post reproductive health·2021
    Same author

    Growth and digestive enzyme activities of rohu labeo rohita fed diets containing macrophytes and almond oil-cake.

    Animal feed science and technology·2020
    Same author

    Do differences in compositional time use explain ethnic variation in the prevalence of obesity in children? Analyses using 24-hour accelerometry.

    International journal of obesity (2005)·2019
    Same author

    Artificial intelligence and the radiologist: the future in the Armed Forces Medical Services.

    BMJ military health·2019
    Same journal

    Assisted dying and the silencing of medicine's next generation.

    Lancet (London, England)·2026
    Same journal

    Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

    Lancet (London, England)·2026
    Same journal

    Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

    Lancet (London, England)·2026
    Same journal

    [<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

    Lancet (London, England)·2026
    Same journal

    Research priorities for characterising Bundibugyo virus.

    Lancet (London, England)·2026
    Same journal

    Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

    Lancet (London, England)·2026
    See all related articles

    Severe hypertriglyceridemia is linked to a hypercoagulable state, increasing cardiovascular risk. Treatment significantly improves triglyceride levels and blood clotting factors, suggesting energetic therapy is warranted.

    Area of Science:

    • Cardiovascular Medicine
    • Hematology
    • Metabolic Disorders

    Background:

    • Severe hypertriglyceridemia is associated with elevated plasma fibrinogen and clotting factor Xc.
    • Patients with hypertriglyceridemia exhibit significantly lower fibrinolytic activity.
    • These hemostatic abnormalities are potential risk factors for cardiovascular disease.

    Purpose of the Study:

    • To investigate the hemostatic profile in patients with severe hypertriglyceridemia.
    • To evaluate the impact of triglyceride-lowering therapy on coagulation and fibrinolysis.

    Main Methods:

    • Comparison of plasma fibrinogen, clotting factors VIIc and Xc, and fibrinolytic activity between 18 hypertriglyceridemic patients and a normolipidaemic control group.
    • Assessment of changes in these parameters after 6 months of treatment with diet or diet and clofibrate.

    Related Experiment Videos

    Main Results:

    • Hypertriglyceridemic patients showed higher fibrinogen and factor Xc, and lower fibrinolytic activity compared to controls.
    • Treatment reduced plasma triglycerides to 3.1 mmol/l, decreased clotting factors VIIc and Xc, and increased fibrinolytic activity.
    • No significant changes were observed in the control group.

    Conclusions:

    • Severe hypertriglyceridemia may be associated with a hypercoagulable state, indicated by altered coagulation and fibrinolytic parameters.
    • Therapeutic intervention to lower triglycerides can ameliorate these hemostatic abnormalities.
    • These findings support aggressive management of severe hypertriglyceridemia due to its potential link to cardiovascular risk.