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Immunoglobulin allotype markers in gluten-sensitive enteropathy.

M F Kagnoff, J B Weiss, R J Brown

    Lancet (London, England)
    |April 30, 1983
    PubMed
    Summary

    Gluten-sensitive enteropathy susceptibility may involve genes linked to immunoglobulin heavy chains, not just major histocompatibility genes. This finding could impact understanding of celiac disease genetics.

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    Area of Science:

    • Immunogenetics
    • Gastroenterology
    • Human Genetics

    Background:

    • Gluten-sensitive enteropathy (celiac disease) is an immune-mediated disorder.
    • Genetic factors, particularly HLA genes, are known contributors to celiac disease risk.

    Purpose of the Study:

    • To investigate the role of immunoglobulin allotype markers in gluten-sensitive enteropathy.
    • To explore potential genetic links beyond the major histocompatibility complex.

    Main Methods:

    • Compared immunoglobulin allotype markers and HLA-A, HLA-B, HLA-DR antigens in 30 patients with gluten-sensitive enteropathy and 30 controls.
    • Matched controls for age, ethnicity, and geographic origin.

    Main Results:

    • Patients lacking specific HLA antigens (HLA-B8, HLA-DR3) frequently exhibited the IgG (Gm) immunoglobulin heavy-chain phenotype Gm (f;n;b).

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  • This suggests a correlation between immunoglobulin heavy-chain allotypes and disease presence in the absence of certain HLA types.

    • Conclusions:

    • Genes linked to the immunoglobulin heavy-chain allotype locus on chromosome 14 may influence susceptibility to gluten-sensitive enteropathy.
    • Genetic susceptibility involves both major histocompatibility locus genes and potentially immunoglobulin heavy-chain-linked genes.