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[Cataplectic falls disclosing hypercalcemia].

B Laurent, G Chazot, A Blanc

    Presse Medicale (Paris, France : 1983)
    |March 19, 1983
    PubMed
    Summary
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    Hypercalcaemic encephalopathy can cause sudden, isolated cataplexy-like falls. Correcting high calcium levels resolved these neurological symptoms, suggesting a link to brainstem metabolic disturbances.

    Area of Science:

    • Neurology
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Hypercalcaemic encephalopathy presents with diverse neurological symptoms.
    • Cataplexy, often associated with narcolepsy, is rarely linked to hypercalcemia.

    Observation:

    • Three patients exhibited isolated cataplexy-like falls without loss of consciousness.
    • One patient experienced frequent falls (every 5-10 seconds) with global hypotonia, unrelated to EEG changes.

    Findings:

    • Neurological symptoms, including cataplexy-like falls, resolved after correcting hypercalcemia.
    • Treatment involved parathyroid adenoma excision or calcitonin injections.
    • The mechanism is likely related to metabolic disturbances in the brainstem reticular system.

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    Implications:

    • This study highlights a novel clinical manifestation of hypercalcaemic encephalopathy.
    • It suggests a potential role for calcium metabolism in brainstem function and neuromediators.
    • Further research is warranted to elucidate the precise mechanisms linking calcium and brainstem function.