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Updated: Jul 25, 2026

Simultaneous Assessment of Cardiomyocyte DNA Synthesis and Ploidy: A Method to Assist Quantification of Cardiomyocyte Regeneration and Turnover
Published on: May 23, 2016
Ploidy in the hearts of elderly patients
Abstract:
The DNA-ploidy of the left and right ventricular wall in 48 patients aged 80-98 years was investigated by scanning cytophotometry. The great variation in nuclear ploidy previously described in the heart muscle was shown to persist during the ninth decade. In addition, the percentage of nuclei with more than 2C DNA content in both ventricles correlated with the degree of coronary stenosis, and in the right ventricle with the presence and severity of pulmonary emphysema, and with the duration of digitalis therapy where this drug was given.
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