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Distigmine bromide and post-prostatectomy voiding.

P J Shah, P H Abrams, R G Choa

    British Journal of Urology
    |April 1, 1983
    PubMed
    Summary
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    Distigmine bromide, an anticholinesterase, showed a trend towards improving bladder voiding after prostatectomy but did not significantly enhance post-operative outcomes or reduce re-catheterisation rates in this study.

    Area of Science:

    • Urology
    • Pharmacology
    • Clinical Trials

    Background:

    • Distigmine bromide is a long-acting anticholinesterase medication.
    • It is believed to enhance detrusor muscle function and restore normal voiding patterns.
    • Autonomic overactivity can disrupt voiding, especially after surgery like prostatectomy.

    Purpose of the Study:

    • To evaluate the efficacy of distigmine bromide in improving post-prostatectomy voiding.
    • To assess the effect of distigmine bromide on urinary flow rates, bladder volume, and re-catheterisation incidence.

    Main Methods:

    • A double-blind, placebo-controlled study was conducted.
    • Ninety-three patients undergoing prostatectomy were included.
    • Patients received either distigmine bromide or a placebo post-surgery.

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    Main Results:

    • A trend towards improved voiding parameters was observed with distigmine bromide.
    • No statistically significant differences were found in post-operative flow rates.
    • There was no significant reduction in bladder volume or re-catheterisation incidence compared to placebo.

    Conclusions:

    • Distigmine bromide did not demonstrate statistically significant benefits for post-prostatectomy voiding in this trial.
    • Further research may be needed to clarify its role in managing post-surgical urinary dysfunction.