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Somatostatin and the interdigestive migrating motor complex in man.
Regulatory Peptides
|February 1, 1983
Summary
Somatostatin levels rise with the migrating motor complex (MMC) activity front in the duodenum. Exogenous somatostatin inhibits gastric activity and alters intestinal motility, suggesting a role in MMC regulation.
Area of Science:
- Gastroenterology
- Endocrinology
- Physiology
Background:
- The interdigestive migrating motor complex (MMC) is crucial for gastrointestinal motility.
- The role of somatostatin in regulating the MMC is not fully understood.
Purpose of the Study:
- To investigate the relationship between endogenous somatostatin and the human MMC.
- To determine the effects of exogenous somatostatin on gastrointestinal motility and hormone levels.
Main Methods:
- Manometric monitoring of gastric and small intestinal motility in human volunteers.
- Radioimmunoassay of plasma somatostatin, motilin, and pancreatic polypeptide.
- Intravenous infusion of somatostatin at varying doses.
Main Results:
- Endogenous somatostatin levels peaked during the activity front progression into the duodenum.
- Exogenous somatostatin dose-dependently inhibited gastric activity and abolished intestinal phase 2 of the MMC.
- Somatostatin infusion stimulated intestinal phase 3 of the MMC and decreased motilin and pancreatic polypeptide levels.
Conclusions:
- Somatostatin appears to play a physiological role in the regulation of the MMC.
- Somatostatin may facilitate the progression of the MMC activity front into the small intestine.