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The Salmonella/mammalian-microsome assay: variations of the test protocol; results of a questionnaire returned by 87
Teratogenesis, Carcinogenesis, and Mutagenesis
|January 1, 1983
Abstract:
The answers to a questionnaire sent to 147 laboratories in Europe using the Salmonella/mammalian-microsome assay are presented. In mutagenicity testing, where research projects in environmental mutagenesis predominate, the Salmonella/mammalian-microsome assay is the most often used test. Of all laboratories that answered the questionnaire, 80% are using the test with occasional modifications (preincubation, fluctuation test). Most of the differences concern the activation system used. This questionnaire is part of a European collaborative study which aims to improve the standardization of the Salmonella/mammalian-microsome assay.