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The neural crest: its relations with APUD and paraneuron concepts
Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku
|December 1, 1982
Summary
Neural crest cells form diverse derivatives, including APUD and paraneuron types. Their common properties may stem from function, not just embryological origin, impacting understanding of these cell systems.
Area of Science:
- Developmental Biology
- Cell Biology
- Neuroscience
Background:
- Neural crest cells are multipotent embryonic cells.
- They differentiate into a wide array of cell types, including neural, mesenchymal, and endocrine cells.
- Previous studies have utilized avian chimeric systems to trace neural crest cell fates.
Purpose of the Study:
- To review evidence for neural crest origin of various cell types.
- To discuss the role of neural crest in the APUD and paraneuron systems.
- To explore the implications for understanding the common properties and pathological significance of these cell derivatives.
Main Methods:
- Review of existing literature and experimental evidence.
- Analysis of studies using Le Douarin's quail/chick marker system.
- Examination of cell lineage tracing and fate mapping data.
Main Results:
- Evidence supports neural crest origin for calcitonin-containing cells, carotid body, aortic paraganglia, and adrenomedulla.
- Evidence argues against a neurectodermal origin for enterogastric and respiratory tract endocrine cells.
- Common properties of these cell types may be functionally, rather than embryologically, determined.
Conclusions:
- The embryological origin alone may not explain the shared characteristics of neural crest derivatives.
- The paraneuron concept and the receptosecretory function of epithelial cells are relevant.
- Neural crest's widespread influence extends beyond APUD and paraneuron systems, questioning its definition as a singular system.