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[Antihistamines and reactivity].

L Moser, H Gerdes, M Bückmann

    Arzneimittel-Forschung
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Astemizole, an antihistamine, did not impair driving or machinery operation abilities in volunteers. Unlike ketotifen, astemizole showed no negative effects on concentration or reactivity, even after seven days of treatment.

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    Area of Science:

    • Pharmacology
    • Neuroscience
    • Human Factors

    Background:

    • Antihistamines are commonly used for allergies.
    • Some antihistamines can cause drowsiness and impair cognitive functions.
    • Assessing the safety of astemizole for driving and machinery operation is crucial.

    Purpose of the Study:

    • To evaluate the effects of astemizole on driving ability and safe machinery operation.
    • To compare astemizole's performance impact against a placebo and a reference drug (ketotifen).

    Main Methods:

    • Double-blind, placebo-controlled studies with 85 healthy volunteers.
    • Psychometric tests measuring objective tiredness, subjective fatigue, concentration, and reactivity.
    • Single administration and seven-day treatment protocols.

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    Main Results:

    • Single dose: No significant difference in performance between astemizole and placebo.
    • Single dose: Ketotifen significantly impaired concentration and reactivity, despite no subjective tiredness.
    • Seven-day treatment: Astemizole group showed no decline in performance compared to placebo.

    Conclusions:

    • Astemizole does not impair driving ability or safe machinery operation.
    • Generalized warnings about antihistamine-induced reactivity impairment may not apply to astemizole.
    • Ketotifen demonstrated significant performance deficits, highlighting drug-specific effects.