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Hornet (Vespa orientalis) venom sac extract causes hepatic injury in cats

M G Neuman, J S Ishay, J Eshchar

    Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
    |January 1, 1983
    PubMed

    Insights

    Sublethal hornet venom injections in cats caused rapid, partially reversible increases in liver enzymes, blood sugar, and electrolytes. These changes suggest potential liver cell injury from hornet venom toxicity.

    Area of Science:

    • Toxicology
    • Veterinary Medicine
    • Biochemistry

    Background:

    • Hornet stings can cause adverse health effects.
    • The specific physiological impact of sublethal hornet venom doses requires further investigation.

    Purpose of the Study:

    • To investigate the acute physiological effects of sublethal hornet venom injection in a feline model.
    • To identify key biochemical and hematological changes induced by hornet venom.

    Main Methods:

    • Cats were injected with sublethal doses of hornet venom.
    • Serum biochemical parameters (aminotransferases, alkaline phosphatase, glucose, urea, potassium) were measured.
    • Blood gas analysis (pH, PO2) was performed.

    Main Results:

    • Significant increases in serum aminotransferases, alkaline phosphatase, glucose, urea, and potassium were observed.
    • A notable decrease in blood pH and PO2 was recorded.
    • All observed changes were evident within 30 minutes and showed partial reversibility.

    Conclusions:

    • The rapid onset and pattern of changes suggest specific liver cell injury as a primary effect of hornet venom.
    • While a generalized metabolic effect like shock is unlikely, the findings warrant further research into venom-induced pathophysiology.

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