Related Experiment Video
Updated: Sep 30, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
[30 years later. The story of the discovery of neuroleptics]
Abstract:
The first trial use of neuroleptics for psychiatric purposes took place on 9 November 1951 at Villejuif psychiatric Hospital. It consisted in the administration of chlorpromazine to a female psychiatrist on the staff of the hospital. The protocol drawn up during the session indicates the characteristic effects of chlorpromazine on the subject's emotional state. The experiment was taken no further at Villejuif. The author subsequently abandoned psychopharmacology in favour of research into psychosomatics.
Related Concept Videos
Psychosis and Antipsychotic Drugs: Overview
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Psychosis: Goals of Pharmacotherapy
Antipsychotic Drugs: Typical and Atypical Agents
Antipsychotic Drugs: Therapeutic Uses and Side Effects
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
Drug Therapy
Antianxiety Medications

