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Related Experiment Videos

Neuroendocrine studies with fluvoxamine: animal data.

S Cella, A Penalva, V Locatelli

    British Journal of Clinical Pharmacology
    |January 1, 1983
    PubMed
    Summary

    Fluvoxamine, a serotonin reuptake inhibitor, impacts male rat endocrine function by altering beta-endorphin and prolactin levels. Tolerance develops to its prolactin-releasing effects, suggesting complex central nervous system interactions.

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    Area of Science:

    • Neuroendocrinology
    • Pharmacology

    Background:

    • Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants.
    • The neuroendocrine effects of SSRIs, such as fluvoxamine, are not fully understood.
    • Serotonin (5-HT) plays a crucial role in regulating various physiological processes, including hormone secretion.

    Purpose of the Study:

    • To investigate the endocrine effects of fluvoxamine in male and female rats.
    • To explore the impact of fluvoxamine on luteinizing hormone, beta-endorphin, and prolactin secretion.
    • To examine the development of tolerance to the prolactin-releasing effects of fluvoxamine.

    Main Methods:

    • Adult male and female rats were administered fluvoxamine (25 mg/kg i.p.) for varying durations.
    • Plasma hormone levels (luteinizing hormone, beta-endorphin, beta-lipotropin, prolactin) were measured.

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  • The effect of fluvoxamine on 5-hydroxytryptophan-induced prolactin release was assessed.
  • Tolerance to fluvoxamine's prolactin-releasing effect was studied after chronic administration and withdrawal.

    • Main Results:

    • Fluvoxamine did not affect estrous cycles or luteinizing hormone in female rats.
    • In male rats, fluvoxamine decreased anterior pituitary beta-endorphin and increased plasma beta-endorphin and beta-lipotropin.
    • Fluvoxamine stimulated prolactin secretion in male rats and potentiated 5-hydroxytryptophan's effect.
    • Chronic fluvoxamine treatment led to tolerance in prolactin release, which persisted after drug withdrawal.

    Conclusions:

    • Acute fluvoxamine administration activates central 5-HT neurotransmission, leading to specific endocrine changes in male rats.
    • Tolerance to the prolactin-releasing effect of fluvoxamine suggests complex adaptive mechanisms.
    • Understanding these mechanisms could offer insights into the action of SSRIs used in treating depression.