[Catecholamine content in the myocardium of growing rats with alpha- and beta-adrenergic blockades]

Studies of the effect of a single intraperitoneal injection of the alpha-adrenoblockers, phentolamine and dibenamine (5 mg/kg) and the beta-adrenoblockers, anapriline and alpheprol (1 mg/kg) into rats aged 7, 30 days and 3-5 months have demonstrated that as regards the degree of the changes in noradrenaline and adrenaline levels, the 7-day-old animals are more susceptible to the alpha-adrenoblockers, while the 30-day-old ones to the drugs of both groups. A relationship has been noticed between the age, the grade of the development of the adrenergic apparatus of the heart, metabolism of this organ and the pharmacodynamics of the adrenoblockers.