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Biochemical and pathological changes in experimental phycomycosis.

M J Corbel, P Hambleton, A Baskerville

    Journal of Comparative Pathology
    |April 1, 1983
    PubMed
    Summary
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    Intravenous inoculation of Absidia corymbifera spores caused acute phycomycosis in rabbits, leading to widespread organ damage, particularly in the kidneys. The infection significantly altered serum biochemistry, indicating a severe systemic response.

    Area of Science:

    • Mycology
    • Veterinary Pathology
    • Clinical Biochemistry

    Background:

    • Absidia corymbifera is a fungus known to cause opportunistic infections.
    • Phycomycosis is a severe fungal infection with high mortality rates.
    • Understanding the systemic effects of A. corymbifera infection is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate the pathological and biochemical changes associated with acute phycomycosis induced by Absidia corymbifera in rabbits.
    • To characterize the progression of the infection and its impact on organ systems and serum parameters.

    Main Methods:

    • Rabbits were intravenously inoculated with Absidia corymbifera spores.
    • Fungal infection progression was monitored through cultural and microscopical examinations.

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  • Serum biochemistry, including electrolytes, enzymes, proteins, and lipids, was analyzed.

    • Main Results:

    • Intravenous inoculation led to acute, widespread phycomycosis and death within 2-10 days.
    • Kidneys showed extensive lesions, with widespread organ system involvement.
    • Significant alterations in serum biochemistry were observed, including decreased iron and zinc, increased acute-phase proteins, and elevated urea during the terminal phase.

    Conclusions:

    • Absidia corymbifera infection in rabbits causes acute, fatal phycomycosis with extensive renal pathology.
    • The infection triggers a complex systemic response, reflected in significant changes in serum biochemistry.
    • These findings highlight the severe impact of A. corymbifera and provide insights into disease markers.