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Related Experiment Videos

[Teratogenicity study on ranitidine hydrochloride in rats].

N Higashida, S Kamada, M Sakanoue

    The Journal of Toxicological Sciences
    |January 1, 1983
    PubMed
    Summary

    Ranitidine hydrochloride, a histamine H2-receptor antagonist, did not increase birth defects or affect offspring development in rats. This study found no adverse teratogenic effects from ranitidine treatment during gestation.

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    Yamaoka Nozomu, a 'humanistic' historian of chemistry.

    Historia scientiarum : international journal of the History of Science Society of Japan·1993

    Area of Science:

    • Pharmacology
    • Toxicology
    • Developmental Biology

    Context:

    • Ranitidine hydrochloride is a widely used histamine H2-receptor antagonist.
    • Assessing drug safety during pregnancy is crucial for maternal and fetal health.
    • Teratogenicity studies evaluate potential risks of developmental abnormalities.

    Purpose:

    • To investigate the potential teratogenic effects of ranitidine hydrochloride in pregnant rats.
    • To assess the impact of ranitidine on fetal development and postnatal growth.
    • To determine the safety profile of ranitidine during critical periods of gestation.

    Summary:

    • Pregnant rats received oral doses of ranitidine hydrochloride (50, 200, 800 mg/kg/day) from day 7 to 17 of gestation.
    • Fetal examination and postnatal development assessments revealed no significant increase in external, internal, or skeletal anomalies.

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  • Ranitidine treatment did not affect parturition, lactation, offspring growth, or reproductive capacity.

    • Impact:

    • Provides evidence for the lack of teratogenicity of ranitidine hydrochloride in a rodent model.
    • Informs risk assessment for ranitidine use during pregnancy.
    • Contributes to the understanding of histamine H2-receptor antagonist safety in developmental toxicology.