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[Fertility study on ranitidine hydrochloride in rats]
The Journal of Toxicological Sciences
|January 1, 1983
Summary
Ranitidine hydrochloride, a histamine H2-receptor antagonist, showed no adverse effects on rat fertility or embryonic development. This study confirms its safety for reproductive parameters in preclinical models.
Area of Science:
- Pharmacology
- Toxicology
- Reproductive Science
Context:
- Ranitidine hydrochloride is a widely used histamine H2-receptor antagonist.
- Assessing the reproductive safety of pharmaceuticals is crucial for human health.
Purpose:
- To evaluate the effects of ranitidine hydrochloride on the fertility and embryonic development of rats.
- To determine any potential teratogenic effects of ranitidine hydrochloride administration.
Summary:
- Rats were orally administered ranitidine hydrochloride at 50, 200, and 800 mg/kg/day.
- No significant adverse effects on mating, fertilization, implantation, or embryonic development were observed.
- Temporary salivation was noted at higher doses, but no fetal abnormalities were detected.
Impact:
- Provides evidence for the safety of ranitidine hydrochloride concerning reproductive and developmental toxicity.
- Informs regulatory assessments and clinical use of ranitidine hydrochloride.