Urothelial dysplasia concomitant with bladder tumours as a determinant factor for future new occurrences

Of 53 patients with primary bladder tumours of categories T1 or T2 about 50% had concomitant urothelial dysplasia, either carcinoma-insitu or less dedifferentiated dysplasia graded as grade II. In a follow-up study of these patients treated with transurethral resection alone, it was found that new occurrences had developed in 87% of patients with concomitant urothelial dysplasia, compared with 26% of those without dysplasia. Most new occurrences developed within 6 months of initial tumour resection. A new invasive tumour developed in all patients with concomitant carcinoma-in-situ, emphasising the serious prognostic significance of that entity. Thus, urothelial dysplasia concomitant with a bladder tumour is an important determinant factor for future new occurrences.