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Related Experiment Videos

Antihistamines and sedation.

A N Nicholson

    Lancet (London, England)
    |July 23, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Careful antihistamine use can minimize central effects like sedation, preserving therapeutic activity. Some individuals may develop tolerance, and specific formulations offer improved daytime sedation control.

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    Area of Science:

    • Pharmacology
    • Allergy and Immunology

    Background:

    • Antihistamines are widely used for allergic conditions.
    • Central nervous system (CNS) effects, particularly sedation, are common side effects.
    • Minimizing sedation while maintaining peripheral efficacy is a clinical challenge.

    Purpose of the Study:

    • To evaluate strategies for minimizing central nervous system effects of antihistamines.
    • To assess the potential for tolerance to antihistamine-induced sedation.
    • To identify antihistamines suitable for patients experiencing troublesome daytime sedation.

    Main Methods:

    • Review of existing literature on antihistamine pharmacology and clinical use.
    • Analysis of pharmacokinetic and pharmacodynamic properties of various antihistamine agents.

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  • Consideration of drug formulations, including sustained-release options.

    • Main Results:

    • Central effects of antihistamines can be minimized with careful drug selection and usage.
    • Tolerance to sedative effects may develop rapidly with certain antihistamines.
    • Sustained-release formulations and evening dosing can reduce next-day sedation.
    • Astemizole, mequitazine, and terfenadine show promise for sedation-intolerant patients.

    Conclusions:

    • Judicious use of antihistamines can balance peripheral activity with reduced central side effects.
    • Individual patient responses to antihistamines vary, and sedation cannot be entirely eliminated.
    • Specific antihistamines and administration strategies can improve tolerability for patients sensitive to sedation.