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Is there a tardive dysmentia?

I C Wilson, J C Garbutt, C F Lanier

    Schizophrenia Bulletin
    |January 1, 1983
    PubMed
    Summary

    Long-term antipsychotic drug use may cause tardive dysmentia, a behavioral disorder impacting affect and interaction. This condition may contribute to the evolving presentation of schizophrenia.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Schizophrenia phenomenology has shifted, with increased affective disturbances and phasic courses observed.
    • Antipsychotic drug use over the last 30 years is the most significant change in schizophrenia treatment.
    • Chronic antipsychotic treatment is known to cause tardive dyskinesia and potentially supersensitivity psychosis.

    Purpose of the Study:

    • To describe a novel behavioral disorder, tardive dysmentia, associated with long-term antipsychotic treatment.
    • To hypothesize the role of tardive dysmentia in the changing course of schizophrenia.

    Main Methods:

    • Observational study describing clinical phenomenology.
    • Hypothesis generation based on existing knowledge of antipsychotic side effects.

    Main Results:

    • A behavioral disorder termed tardive dysmentia is described, characterized by changes in affect, activation level, and interpersonal interaction.
    • A potential relationship between tardive dysmentia and tardive dyskinesia is suggested.

    Conclusions:

    • Tardive dysmentia is hypothesized to be a consequence of long-term antipsychotic drug treatment.
    • This condition may contribute to the observed changes in the course and presentation of schizophrenia.

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