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Nasal histamine sensitivity in allergic rhinitis.

M Okuda, H Ohtsuka, K Sakaguchi

    Annals of Allergy
    |July 1, 1983
    PubMed
    Summary

    Nasal allergy patients show varying histamine sensitivity based on nasal site and size, linked to antigen reactions. This sensitivity, possibly starting in childhood, involves heightened histamine receptors and autonomic nervous system dysfunction.

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    Area of Science:

    • Allergy and immunology
    • Otolaryngology
    • Nasal physiology

    Background:

    • Nasal allergy is a common condition affecting quality of life.
    • Histamine is a key mediator in allergic rhinitis.
    • Understanding nasal histamine sensitivity is crucial for effective treatment.

    Purpose of the Study:

    • To investigate nasal histamine sensitivity in patients with allergic rhinitis.
    • To explore correlations between histamine sensitivity, antigen provocation, and nasal characteristics.
    • To determine the developmental and physiological factors influencing nasal histamine sensitivity.

    Main Methods:

    • Assessment of histamine sensitivity at different nasal mucosal sites and sizes.
    • Correlation analysis with antigen provocation test results.
    • Evaluation of histamine receptor sensitivity and autonomic nervous system function.

    Main Results:

    • Nasal histamine sensitivity varied significantly based on the location and dimensions of the nasal mucosa.
    • Sensitivity was directly correlated with the intensity of the reaction to antigen challenge.
    • Established sensitivity in childhood was observed, linked to heightened histamine receptors and nasal autonomic dysfunction.

    Conclusions:

    • Nasal histamine sensitivity is a complex trait influenced by anatomical and physiological factors.
    • Early-life development plays a role in establishing histamine sensitivity in allergic rhinitis.
    • Targeting histamine receptors and autonomic dysfunction may offer therapeutic strategies for nasal allergy.

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