[Effect of rausedyl and pyrroxan on autoregulation of cerebral circulation]

Acute experiments were made on dogs under morphine analgesia and local novocaine anesthesia with extracorporeal respiration to determine autoregulatory reactions (AR) of brain vessels to different levels of arterial pressure (AP). The experiments indicated that 12 h after rausedyl injection (1 mg/kg s.c.) there occurred the relaxation of AR to the AP lowering without essential changes in AR to the AP elevation. Twenty to 40 minutes after pyrroxan injection (0.5 mg/kg i.v.) AR were reduced, while AP increased, whereas during AP fall, AR improved. Possible mechanisms of the evidence obtained are discussed.