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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

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Related Experiment Video

Updated: May 12, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Clostridium difficile and inflammatory bowel disease.

C Greenfield, J R Aguilar Ramirez, R E Pounder

    Gut
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Clostridium difficile was found in inflammatory bowel disease patients at rates similar to diarrhea patients, but higher than healthy individuals. Its presence correlated with hospital admission, not disease relapse.

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    Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
    06:51

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    Published on: December 10, 2016

    Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
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    Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

    Published on: May 2, 2018

    Chronic Salmonella Infection Induced Intestinal Fibrosis
    08:40

    Chronic Salmonella Infection Induced Intestinal Fibrosis

    Published on: September 22, 2019

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Microbiology

    Background:

    • Inflammatory bowel disease (IBD) patients may be susceptible to infections.
    • Clostridium difficile is a known cause of infectious diarrhea.

    Purpose of the Study:

    • To investigate the prevalence of Clostridium difficile in patients with inflammatory bowel disease.
    • To compare Clostridium difficile rates in IBD patients to control groups.
    • To explore associations between Clostridium difficile and IBD relapse, medication use, and hospital admission.

    Main Methods:

    • Stool samples were collected from 109 IBD patients, 99 diarrhea controls, and 77 healthy controls.
    • Presence of Clostridium difficile or its toxin was assessed in stool samples.
    • Patient data on recent antibiotic use, sulphasalazine use, and clinical assessment of IBD relapse were recorded.
    • Correlation with hospital admission was analyzed.

    Main Results:

    • Clostridium difficile was detected in 13.4% of IBD patients, 11.9% of diarrhea controls, and 1.4% of healthy controls.
    • IBD patients showed lower recent antibiotic use (11%) but high sulphasalazine use (67%) compared to diarrhea controls.
    • Clostridium difficile presence was not linked to IBD relapse but was associated with hospital admission.
    • 28% of IBD patients had at least one positive stool sample for Clostridium difficile during the one-year study.

    Conclusions:

    • Clostridium difficile infection occurs in IBD patients at a significant rate, comparable to other diarrhea patients.
    • Sulphasalazine use may be a factor in IBD patients, while antibiotic use is less common.
    • Clostridium difficile detection in IBD patients warrants consideration, particularly in hospitalized individuals.