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Sublingual lorazepam: a better premedication?

G D Gale, S Galloon, W R Porter

    British Journal of Anaesthesia
    |August 1, 1983
    PubMed
    Summary
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    Sublingual lorazepam (oral transmucosal) is more effective than intramuscular injection for surgical premedication. This method offers faster absorption, leading to earlier drowsiness and better amnesia, with the added benefit of avoiding injection discomfort.

    Area of Science:

    • Pharmacology
    • Anesthesiology
    • Gynecology

    Background:

    • Premedication is crucial for managing patient anxiety and improving surgical outcomes.
    • Lorazepam is commonly used for its anxiolytic and sedative properties.
    • The route of administration can significantly impact drug absorption and efficacy.

    Purpose of the Study:

    • To compare the efficacy of sublingual lorazepam versus intramuscular lorazepam as premedication for minor gynecological surgery.
    • To evaluate the onset, degree, and duration of lorazepam's effects based on administration route.

    Main Methods:

    • A randomized study involving 150 patients undergoing minor gynecological procedures.
    • Lorazepam administered via sublingual preparation or intramuscular injection.

    Related Experiment Videos

  • Assessment of anxiety, arousability, and recall of stimuli to measure drug effects.

    • Main Results:

    • Both sublingual and intramuscular lorazepam reduced anxiety scores.
    • Sublingual lorazepam demonstrated earlier sedation onset, increased drowsiness, and prolonged recovery time.
    • Patients receiving sublingual lorazepam exhibited less recall of stimuli compared to the intramuscular group.

    Conclusions:

    • Sublingual lorazepam is superior to intramuscular administration for surgical premedication.
    • The sublingual route facilitates more rapid absorption, enhancing sedative and amnesic effects.
    • Sublingual administration offers a more comfortable alternative by eliminating injection-related discomfort.