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Experience with combined individualized method of hMG/hCG therapy
International Journal of Fertility
|January 1, 1983
Summary
Gonadotropin therapy effectively treats anovulation, leading to ovulation induction. A combined monitoring approach, including estrogen levels and cervical score, improved pregnancy rates in infertile women.
Area of Science:
- Reproductive Endocrinology
- Infertility Treatment
Background:
- Anovulation syndrome significantly impacts female fertility.
- Ovulation induction agents like gonadotropins offer treatment but require careful monitoring.
- Previous monitoring methods using solely biophysical signs were insufficient.
Purpose of the Study:
- To present a combined, individualized monitoring method for human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) therapy.
- To evaluate the efficacy and outcomes of this combined therapy in infertile anovulatory women.
Main Methods:
- Fifty-one infertile anovulatory women underwent 124 treatment cycles using a combined individualized hMG/hCG therapy.
- Monitoring involved assessing estrogen secretion and cervical score for follicular maturation.
- Therapy success was defined by induced ovulation.
Main Results:
- A strong clinical correlation was observed between cervical score and rising estrogen levels.
- The overall pregnancy rate was 62.7%.
- Sixty percent of patients achieved pregnancy within the first three treatment cycles.
Conclusions:
- Gonadotropin therapy, when monitored effectively, is a highly efficient treatment for anovulatory infertility.
- The combined individualized monitoring approach demonstrated good clinical correlation and high pregnancy rates.
- Despite potential complications like hyperstimulation and multiple gestations, gonadotropin therapy remains a valuable tool.