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Related Experiment Videos

Jejunal function and pathology in visceral Leishmaniasis.

R Muigai, D G Gatei, S Shaunak

    Lancet (London, England)
    |August 27, 1983
    PubMed
    Summary

    Visceral leishmaniasis can impair small intestinal function, affecting nutrient absorption. Treatment with sodium stibogluconate improved absorption and restored intestinal health in patients.

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    Disease markers·2019

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Parasitology

    Background:

    • Visceral leishmaniasis (VL) is a serious parasitic disease.
    • VL can affect various organs, but intestinal involvement is less understood.
    • Malabsorption is a potential complication of VL.

    Purpose of the Study:

    • To investigate small intestinal function in patients with visceral leishmaniasis.
    • To assess the impact of VL on nutrient absorption.
    • To evaluate the effect of treatment on intestinal function and histology.

    Main Methods:

    • Studied 10 patients with visceral leishmaniasis.
    • Assessed vitamin A and d-xylose absorption.
    • Performed intestinal mucosal biopsies to identify Leishmania parasites and assess histology.

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  • Monitored patients after treatment with sodium stibogluconate.

    • Main Results:

    • Impaired vitamin A absorption in 7/10 patients and d-xylose absorption in 1/10.
    • Leishmania parasites found in intestinal biopsies of 5/10 patients.
    • Histological findings included parasitized macrophages, inflammation, and partial villous atrophy in some.
    • No correlation between parasite load and malabsorption severity.
    • Significant improvement in nutrient absorption and normalization of biopsy findings after treatment.

    Conclusions:

    • Visceral leishmaniasis can cause significant small intestinal dysfunction and malabsorption.
    • Intestinal biopsy is valuable for diagnosing VL and assessing its impact.
    • Sodium stibogluconate treatment effectively resolves intestinal manifestations of VL.
    • VL may be an underrecognized cause of chronic diarrhea.