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Congenital malformations in diabetic offspring.

P Temesio, R Belitzky, L Gallego

    Acta Diabetologica Latina
    |September 1, 1977
    PubMed
    Summary

    Congenital malformations (CM) occurred in 9.8% of deliveries to diabetic mothers. This retrospective study found no statistically significant link between CM prevalence and maternal age, diabetes class, angiopathy, treatment, or metabolic control.

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    Area of Science:

    • Obstetrics and Gynecology
    • Neonatology
    • Endocrinology

    Background:

    • Maternal diabetes is a known risk factor for congenital malformations (CM).
    • Understanding the specific risk factors in diabetic pregnancies is crucial for improving outcomes.
    • Previous research suggests various maternal and disease-related factors may influence CM development.

    Purpose of the Study:

    • To investigate the prevalence of congenital malformations (CM) in deliveries to diabetic mothers.
    • To analyze the association between CM and maternal age, diabetes class, angiopathy, treatment, and metabolic control in diabetic pregnancies.

    Main Methods:

    • Retrospective study design.
    • Analysis of 215 deliveries from diabetic mothers at Hospital de Clínicas, Montevideo, Uruguay.
    • Statistical evaluation of potential risk factors including maternal age, diabetes classification, angiopathy, treatment, and metabolic control.

    Main Results:

    • The overall prevalence of congenital malformations (CM) in the study cohort was 9.8%.
    • No statistically significant associations were found between the prevalence of CM and maternal age.
    • No statistically significant associations were found between the prevalence of CM and maternal diabetes class, angiopathy, treatment, or metabolic control.

    Conclusions:

    • The study identified a 9.8% prevalence of congenital malformations in deliveries to diabetic mothers.
    • Key maternal and diabetes-related factors analyzed did not show a statistically significant link to CM prevalence in this cohort.
    • Further research may be needed to elucidate potential contributing factors to congenital malformations in diabetic pregnancies.

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