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Haptoglobin polymorphism in the Ladakhi population.

H Kaur, P K Sehajpal, P K Shrivastava

    Acta Geneticae Medicae Et Gemellologiae
    |January 1, 1977
    PubMed
    Summary
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    Haptoglobin (Hp) polymorphism was analyzed in 148 Ladakhis, a Mongoloid population from India. The allele Hp1 frequency was 0.270, aligning with other Mongoloid groups.

    Area of Science:

    • Human Genetics
    • Population Genetics
    • Biochemistry

    Background:

    • Haptoglobin (Hp) is a plasma protein involved in hemoglobin binding.
    • Hp polymorphism exhibits significant population-specific variations.
    • Understanding Hp allele frequencies is crucial for population genetics studies.

    Purpose of the Study:

    • To investigate the haptoglobin (Hp) polymorphism in the Ladakhi population.
    • To determine the allele frequencies of Hp in this specific Mongoloid group.
    • To compare Ladakhi Hp allele frequencies with other Mongoloid populations.

    Main Methods:

    • Blood samples were collected from 148 individuals of Ladakhi origin.
    • Haptoglobin phenotyping was performed using standard electrophoretic techniques.

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  • Allele frequencies were calculated based on observed phenotype distributions.

    • Main Results:

    • The study analyzed haptoglobin (Hp) polymorphism in 148 Ladakhis.
    • The frequency of the Hp1 allele was found to be 0.270.
    • This frequency is comparable to those observed in other Mongoloid populations.

    Conclusions:

    • The haptoglobin (Hp) allele frequencies in Ladakhis are consistent with those of other Mongoloid populations.
    • This finding contributes to the understanding of genetic diversity in Himalayan populations.
    • Further research can explore the functional implications of Hp polymorphism in this region.