Vasoactive intestinal polypeptide as a neurotransmitter in the female genital tract

Vasoactive intestinal polypeptide (VIP) has been demonstrated in nerve fibers of the female genital tract localized in synaptic vesicles. The VIP-containing nerve fibers seem to innervate nonvascular smooth muscle, blood vessels, and epithelial cells. Evidence is accumulating that VIP fulfills a number of the classical criteria to be a neurotransmitter in the female genital tract. It is likely that VIP is the mediator of genital functions, which are controlled by noncholinergic, nonadrenergic nerve fibers. VIP seems to play a role in the local nervous control of uterine smooth muscle, e.g., opening of the uterotubal junctions, and to be involved in vasodilatation in the uterus as wells as the vagina. In conclusion, a third or peptidergic division of the autonomic nervous system seems to participate in the nervous control of reproduction.