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Effect of insulin-treatment on age-dependent decrease of lipogenic enzyme induction.

H Fukuda, N Iritani

    Biochimica Et Biophysica Acta
    |October 4, 1983
    PubMed
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    Insulin treatment impacts liver lipogenic enzyme induction differently with age. In older rats, insulin shortens enzyme induction lag times, suggesting insulin binding

    Area of Science:

    • Biochemistry
    • Metabolism
    • Endocrinology

    Background:

    • A fat-free diet induces liver lipogenic enzymes.
    • Enzyme induction magnitude decreases with rat age.
    • Insulin's role in this age-dependent induction is unclear.

    Purpose of the Study:

    • To investigate the effects of insulin treatment on the induction of liver lipogenic enzymes in rats of different ages (1, 2, and 9 months).
    • To explore the relationship between insulin binding capacity and lipogenic enzyme induction in aging rats.

    Main Methods:

    • Rats of varying ages were fed a fat-free diet.
    • Insulin injections were administered to assess their impact on enzyme induction.
    • Insulin binding capacities to liver plasma membranes and adipocytes were measured.

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    Main Results:

    • Lipogenic enzyme induction was highest in young rats and decreased with age.
    • Insulin injection did not affect induction in young rats.
    • In older rats, insulin shortened induction lag periods but did not alter maximal enzyme levels.
    • Enzyme induction in older rats correlated with insulin binding capacity, not plasma insulin levels.

    Conclusions:

    • Age-dependent decreases in lipogenic enzyme induction are linked to altered insulin binding.
    • Insulin binding capacity plays a crucial role in regulating lipogenic enzyme induction during aging.