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Evidence for a widely distributed peripheral dopaminergic system.

Z Lacković, M Relja

    Federation Proceedings
    |October 1, 1983
    PubMed
    Summary
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    Dopamine (DA) is likely a widespread neurotransmitter in the autonomic nervous system. Evidence suggests its presence in peripheral nerves, with plasma DA levels reflecting nervous system activity, indicating a broad dopaminergic system.

    Area of Science:

    • Neuroscience
    • Autonomic Nervous System Research

    Background:

    • Dopamine (DA) is a known neurotransmitter in the central nervous system.
    • Its role in the peripheral autonomic nervous system is less understood.

    Purpose of the Study:

    • To investigate the hypothesis that dopamine acts as a neurotransmitter or cotransmitter in the autonomic nervous system.
    • To explore the distribution and function of dopamine in peripheral tissues.

    Main Methods:

    • Morphological identification of DA-containing neurons and axons in autonomic ganglia and peripheral organs.
    • Pharmacological experiments to assess dopaminergic nerve activity.
    • Biochemical analysis of DA metabolism and receptor distribution in various tissues.
    • Measurement of plasma DA concentrations and correlation with autonomic nervous system activity.

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    Main Results:

    • DA-containing neurons and dopaminergic axons were found in autonomic ganglia and specific tissues like the kidney and paw pad.
    • Pharmacological evidence suggested dopaminergic nerves in the vas deferens, stomach, and mesenteric artery.
    • Intensive DA catabolism was observed in peripheral tissues of rats and humans.
    • Widespread distribution of dopaminergic receptors and significant plasma DA levels, not solely from the adrenal gland, were noted.
    • Plasma DA concentration correlated with autonomic nervous system activity.

    Conclusions:

    • The findings support the hypothesis of dopamine as a widely distributed neurotransmitter/cotransmitter in the autonomic nervous system.
    • The presence of DA and its metabolites in peripheral nerves suggests a significant peripheral dopaminergic system.